Çoban, Zehra Dilşad Gülhane Military Medical Academy - Department of Medical Biology, Turkey , Güran, Şefik Gülhane Military Medical Academy - Department of Medical Biology, Turkey , Torun, Deniz Gülhane Military Medical Academy - Department of Medical Genetics, Turkey , Kozan, Salih Gülhane Military Medical Academy - Department of Medical Genetics, Turkey , Dede, Murat Gülhane Military Medical Academy - Department of Obstetrics and Gynecology, Turkey , Keskin, Uğur Gulhane Military Medical Academy - Department of Obstetrics and Gynecology, Turkey , Yenen, Müfit Cemal Gülhane Military Medical Academy - Department of Obstetrics and Gynecology, Turkey

Predisposition of papillary thyroid carcinoma in a family dignosed as hereditary breast and ovarian cancer syndrome

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Hereditary breast and ovarian cancer syndrome is characterized by the familial type of breast and/or ovarian cancers diagnosed at early onset. In these families, predisposition to prostate and pancreas cancers can be seen. Here a family who had hereditary breast and ovarian cancer syndrome was presented and we also discussed the possible mechanisms in the predisposition of papillar type thyroid cancer which is common in this family. No BRCA 1 and BRCA 2 mutation had been observed in certain loci in this family. Due to the literature findings, our family is the sole example which has clinically hereditary breast and ovarian cancer syndrome diagnosis with thyroid papillary carcinoma predisposition.Here, there may be a common mechanism affected in these different tumors. So, further studies are necessary to find out affected pathways in patients having hereditary type breast and ovarian cancer who has also predispositionto papillary thyroid carcinoma.

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Hereditary breast and ovarian cancer syndrome , papillary thyroid carcinoma , BRCA 1 , BRCA 2 , hereditary cancers

Cumhuriyet Medical Journal

334