Yücel, Birsen Cumhuriyet Üniversitesi - Tıp Fakültesi - Radyasyon Onkolojisi Anabilim Dalı, Turkey , Akkaş, Ebru Atasever Sivas Numune Hastanesi - Radyasyon Onkolojisi Kliniği, Turkey , Erdiş, Eda Antakya State Hospital - Radyasyon Onkolojisi Kliniği, Turkey , Okur, Yıllar Ankara Numune Hastanesi - Radyasyon Onkolojisi Kliniği, Turkey , Eren, Mehmet Fuat Cumhuriyet Üniversitesi - Tıp Fakültesi - Radyasyon Onkolojisi Anabilim Dalı, Turkey , Babacan, Nalan Cumhuriyet Üniversitesi - Tıp Fakültesi - Tıbbi Onkoloji Bilim Dalı, Turkey , Kaçan, Turgut Cumhuriyet Üniversitesi - Tıp Fakültesi - Tıbbi Onkoloji Bilim Dalı, Turkey , Kılıçkap, Saadettin Cumhuriyet Üniversitesi - Tıp Fakültesi - Tıbbi Onkoloji Bilim Dalı, Turkey

Patients with brain tumors were evaluated retrospectively after radiotherapy

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Aim: The purpose of this study is to review survival analysis, side effects and prognostic factors inpatients with brain tumors who were treated with adjuvant radiotherapy or chemoradiotherapy.Methods. In this study, we retrospectively evaluated data of 76 patients with brain tumorsfollowed-up at Cumhuriyet University Medical Faculty of Oncology Centre. Results. This studyanalysed data belonging to 76 patients; 51 (67%) men, and 25 (33%) women. There werehistopathologicly low-grade gliomas in 18 (%24) patients, high-grade gliomas in 17 (%22)patients, glioblastoma multiforme in 33 (%44), pituitary adenomas in 4 (%5) patients andmedullablastoma in 4 (%5) patients. The median follow-up was 16 months (range, 1-199). The 2-year overall and disease-free survival were 83% and 83% at low-grade gliomas, 46% and 40% athigh-grade gliomas, 28% ve 24% at glioblastoma multiforme, respectively. The factors thatdetermined survival were histopathology (p 0,001), age (≤50 and 50, p 0,001), grade (p: 0,003),Ki-67 value (≤10 and 10, p: 0,016), Eastern Cooperative Oncology Group performance status (p:0,006) and surgery (biopsy vs total resection p: 0,017). Eastern Cooperative Oncology Groupperformance status (p 0,001) and histopathology (p: 0,022) were determined as indepentprognostic factors that affect survival after multivariate analysis. The most acute side effects were headaches in 51 (%67) patients, nausea and vomiting in 32 (%42) patients. Radionecrosis was diagnosed in 3 (%5) patients. Conclusion. It was showed that the overall survival and disease-free survival complied with the literature in high-grade gliomas and glioblastoma multiforme except low-grade gliomas. The most prognostic factors were grade, age and Eastern Cooperative Oncology Group performance status in this patients.

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Brain tumors , survival , prognosis

Cumhuriyet Medical Journal

288