Author/Authors :
Tezcan, Büşra Türkiye Yüksek İhtisas Teaching and Research Hospital - Anesthesiology and Reanimation Clinic, Turkey , Uluer, Pınar Durak Türkiye Yüksek İhtisas Teaching and Research Hospital - Anesthesiology and Reanimation Clinic, Turkey , Demir, Aslı Türkiye Yüksek İhtisas Teaching and Research Hospital - Anesthesiology and Reanimation Clinic, Turkey , Aydınlı, Bahar Türkiye Yüksek İhtisas Teaching and Research Hospital - Anesthesiology and Reanimation Clinic, Turkey , Tokat, Sevil Türkiye Yüksek İhtisas Teaching and Research Hospital - Anesthesiology and Reanimation Clinic, Turkey , Taşlıpınar, Mine Gazi Üniversitesi - School of Medicine - Department of Biochemistry, Turkey , Atabey, Mustafa Cumhuriyet University - School of Medicine - Department of General Surgery, Turkey , Erdemli, Özcan Türkiye Yüksek İhtisas Eğitim ve Araştırma Hastanesi - Anesteziyoloji ve Reanimasyon Kliniği, Turkey
Abstract :
Aim. Volatile anesthetics may represent a choice to attenuate oxidant effects. The aim of this study is to investigate the antioxidant status during sevoflurane and desflurane anesthesia immediately before coronary artery bypass graft surgery (CABG) with malondialdehyde (MDA), superoxide dismutase (SOD) and gluthation peroxidase (GPx). Methods. Forty patients, undergoing coronary artery bypass surgery, were enrolled in the study and randomized into two groups of 20 patients each. Anesthesia was maintained with 40% oxygen in air mixture, 1 minimum alveolar concentration (MAC) of desflurane in Group D and sevoflurane in Group S. Blood sampling for the measurements of MDA, SOD and GPx were performed at, T1-before anesthesia induction (baseline), T2-before surgical incision (about 20 min after T1), T3-before cardiopulmonary bypass (about 60 min after T2). Results. Plasma concentrations of MDA, SOD and GPx levels increased significantly during T2 and T3 periods as compared with the baseline values in both groups. This increase was greater in group D versus group S. Conclusion. We conclude that desflurane may cause more systemic lipid peroxidation than sevoflurane during immediately before CABG.
NaturalLanguageKeyword :
Cardiac anesthesia , desflurane , sevoflurane , oxidative stress , antioxidant effect
