Author/Authors :
Çoban, Zehra Dilşad Gülhane Military Medical Academy - Department of Medical Biology, Turkey , Torun, Deniz Gülhane Military Medical Academy - Department of Genetics, Turkey , Avcu, Ferit Gülhane Military Medical Academy - Department of Hematology, Turkey , Ural, Ali Uğur Gülhane Military Medical Academy - Department of Hematology, Turkey , Parıltay, Erhan Gülhane Military Medical Academy - Department of Genetics, Turkey , Kozan, Salih Gülhane Military Medical Academy - Department of Genetics, Turkey , Güran, Şefik Gülhane Military Medical Academy - Department of Medical Biology, Turkey
Abstract :
Aim. Multiple myeloma and plasma cell leukemia are cancers of plasma cells. Multiple myeloma rarely transforms to plasma cell leukemia during the progression period. Zinc as a chemical element modulates proliferation and differentiation of cells by affecting several growth factors. Zip 4 modifies zinc metabolism in a cell as a transporter protein. While high Zip 4 gene expression was found in pancreas and hepatocellular carcinoma, low Zip 4 gene expression was observed in prostate carcinoma. Methods. Here, Zip 4 expression levels were studied in RPMI - 8226 and ARH - 77 cell lines as examples of multiple myeloma and plasma cell leukemia, respectively. Results. We found lower Zip 4 gene expression levels in both cell lines than that of the normal control (0,000157 in RPMI - 8226, 0,000227 in ARH - 77 cell lines and 1 in normal control) The findings were statistically significant (P 0.05). The expression levels of Zip 4 gene in both cell lines were approximately similar. No statistical significance was found between the expression levels of Zip 4 in both cell lines (P = 0.547). Conclusion. The results of this study support the possible role of Zip 4 gene expression in plasma cell dyscrasias. The similar result of Zip 4 gene expression level in both cell lines may show that Zip 4 has no role in the transformation of multiple myeloma to plasma cell leukemia.
NaturalLanguageKeyword :
Zip 4 gene , gene expression , multiple myeloma , plasma cell leukemia
