Author/Authors :
Uygungelen, Bülent Cumhuriyet University - School of Medicine - Department of İnternal Medicine, Turkey , İçağasıoğlu, Serhat Cumhuriyet University - School of Medicine - Department of İnternal Medicine, Turkey , Acıbucu, Fettah Cumhuriyet University - School of Medicine - Department of Endocrinology and Metabolism, Turkey , Kılıçlı, Fatih Cumhuriyet University - School of Medicine - Department of Endocrinology and Metabolism, Turkey , Uslu, Ali Uğur Cumhuriyet University - School of Medicine - Department of İnternal Medicine, Turkey , Gül, İbrahim Cumhuriyet University - School of Medicine - Department of Cardiology, Turkey
Abstract :
Aim. Hypertension is one of the major risk factors for atherosclerosis. Adiponectin is mainly synthesized by white adipose tissue; it is known to have anti-atherogenic and anti-inflammatory effects on endothelial cells and macrophages. Methods. A total of 80 individuals including 48 hypertensive and 32 normotensive individuals were included in the study. Groups were separated as obese and non-obese. Results. It was found out that the patient group had statistically higher systolic blood pressure, diastolic blood pressure, fasting plasma glucose, total cholesterol, triglyceride, low density lipoprotein, high sensitive C reactive protein and microalbuminuria values than the control group while high density lipoprotein values were significantly lower (p 0.05). When adiponectin levels of the groups were compared, the patient group had an adiponectin level of 8.66±2.75 μg/mL and the control group had an adiponectin level of 15.01±3.99 μg/mL. There was a statistically significant difference between two groups (p 0.05). There was a negative correlation between adiponectin level and atherosclerotic risk factors. Conclusion. Adiponectin level was lower in hypertensive group when compared to the control group; there was also a significant association between adiponectin and atherosclerotic risk factors. A low adiponectin level constitutes an important risk for development of atherosclerosis.
