Koçkara, Ayşe Şeker Cumhuriyet Üniversitesi - Tıp Fakültesi - Nefroloji Bilim Dalı, Turkey , Candan, Ferhan Cumhuriyet Üniversitesi - Tıp Fakültesi - Nefroloji Bilim Dalı, Turkey , Hüzmeli, Can Cumhuriyet Üniversitesi - Tıp Fakültesi - Nefroloji Bilim Dalı, Turkey , Kayataş, Mansur Cumhuriyet Üniversitesi - Tıp Fakültesi - Nefroloji Bilim Dalı, Turkey

Comparison of responses to Hepatitis B vaccine in patients with hemodialysis and peritoneal dialysis

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There is generally a failure in humoral and cellular immunity in most of the patients with chronic renal failure (CRF). In this study, the rate of response of CRF patients to a double-dose hepatitis vaccination and the effect of renal replacement type on the formation of antibodies have been investigated. In our centre, 51 hemodialysis (HD) and 19 continuous ambulatory peritoneal dialysis (CAPD) patients were vaccinated with recombinant hepatitis B in the 0th, 1st, 2nd and 6th months. Antibody titrates over 10 mIU/ml seen 1-3 months after the vaccination were considered as a response to the vaccine. As a result, no meaningful difference has been observed between the responses HD and CAPD patients gave to the vaccine (CAPD 84.2%, HD 78.4%, p=0.591). The effects of the duration of the dialysis, sex, age and hemoglobin, total protein, albumin, c-reactive protein (CRP), total cholesterol and triglyceride levels and the positivity of anti- HCV on hepatitis B seroconversion have also been evaluated. Of all these, only the age being over 50 has been seen to have a relationship with insufficient hepatitis B ceroconversion (p=0.037). The other parameters couldn’t be shown to have an effect on the hepatitis B seroconversion (p 0.05).

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Hepatitis B , vaccination , hemodialysis , peritoneal dialysis

Cumhuriyet Medical Journal

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