Eren, Mehmet Fuat Cumhuriyet University - School of Medicine - Department of Radiation Oncology, Turkey , Yücel, Birsen Cumhuriyet University - School of Medicine - Departments of Radiation Oncology, Turkey , Kılıçkap, Sadettin Cumhuriyet University - School of Medicine - Tıbbi Onkoloji Bilim Dalı, Turkey

Venous thromboembolism in cancer patients

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Venous thromboembolism (VTE) is a major complication of cancer and represents an important cause of morbidity and mortality. The incidence of VTE is 0.6-7.8%in patients with cancer more than double the incidence of VTE in patients without cancer. The risk of VTE which includes deep venous thrombosis (DVT) and pulmonary embolism (PE) is increased two to seven fold in patients with cancer. VTE risk is especially high among certain groups such as hospitalized patients with cancer and those receiving active antineoplastic therapy. Also cancer patients, who undergoing major surgery, are increased risk of VTE. Trauma, long-haul travel, increased age, obesity, previous VTE and genetic component are also predisposing factors for VTE. Patients with cancer who develop VTE should be managed multidisciplinary treatment guidelines. The primary goal of thromboprophylaxis in patients with cancer is to prevent VTE. The large majority of cancer patients should be treated with therapeutic doses of unfractioned heparin (UFH) or low molecular weight heparin (LMWH). Prophylaxis should include cancer patients who underwent major surgery for cancer and patients with a history of VTE.

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Venous thromboembolism , cancer , anticoagulation , chemotherapy , low molecular weight heparin

Cumhuriyet Medical Journal

447