Kaya, Hakkı Sivas Numune Hospital - Cardiology Clinic, Turkey , Yücel, Hasan Cumhuriyet University - School of Medicine - Department of Cardiology, Turkey , Zorlu, Ali Cumhuriyet University - School of Medicine - Department of Cardiology, Turkey

Cancer antigen 125 level is determined by tricuspid regurgitation among patients with stable systolic heart failure

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Aim. Cancer antigen 125 (CA-125) is a soluble glycoprotein with high molecular weight. Recently, increased serum CA-125 levels were also documented in patients with heart failure (HF). We aimed to show what factors influence serum levels of CA-125 among patients with chronic systolic HF. Method. Patients, who had chronic systolic HF with echocardiographically determined ejection fraction (EF) 45% were enrolled into final analysis (n=56). CA-125 levels were classified into two as those with normal ( 35 U/mL) and high levels (≥35 U/mL). Results. Patients with Right ventricular (RV) dilatation had significantly higher CA-125 levels compared to those without RV dilatation. Besides, patients with RV dilatation had higher systolic pulmonary artery pressure (SPAP) levels compared to those without. Patients with high CA-125 levels had more frequent RV dilatation, higher pulmonary artery pressure, more severe tricuspid regurgitation. Tricuspid regurgitation was the only significant predictor of high CA-125 levels in patients with stable chronic systolic HF. Conclusion. It was shown in this study that tricuspid regurgitation was the only independent predictor of high CA-125 levels among patients with chronic stable systolic HF.

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CA , 125 , heart failure , right ventricle , tricuspid regurgitation

Cumhuriyet Medical Journal

201