Saini, Savita Pt. B.D. Sharma University of Health Sciences - Department of Anesthesiology Critical Care, India , Mehta, Punit Pt. B.D. Sharma University of Health Sciences - Department of Anesthesiology Critical Care, India , Bansal, Teena Pt. B.D. Sharma University of Health Sciences - Department of Anesthesiology Critical Care, India , Taxak, Susheela Pt. B.D. Sharma University of Health Sciences - Department of Anesthesiology Critical Care, India

A study to compare dexamethasone and ondansetron for preventing postoperative nausea and vomiting in children undergoing tonsillectomy

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Objective: Various drugs have been used as antiemetics for treatment of postoperative nausea and vomiting. The present study was undertaken to assess the efficacy of ondansetron and dexamethasone for preventing postoperative nausea and vomiting in children undergoing tonsillectomies. Method: Sixty children having ASA physical status Grade I or II in the age group 4-12 years undergoing tonsillectomy under general anaesthesia were included in the study. These were allocated to three groups of twenty patient each. After induction patients were given test solution A (2 mL) comprising of normal saline or dexamethasone 500 μg/kg or 150 μg/kg in Group I, II and III respectively. At the end of surgery before switching off anaesthetics, test solution B (2 mL) was given comprising of ondansetron 0.15 mg/kg (maximum upto 4 mg) or normal saline or ondansetron 0.1 mg/kg (maximum upto 2 mg). Postoperatively incidence of nausea, number of vomiting episodes, frequency of administration of rescue antiemetic and analgesic were recorded.Results: In Group II 80% of patients had nausea as compared to 70% in Group I and 50% in group III and the difference between Group II and III was statistically significant (p 0.05). 30% of the patients had vomiting in Group I and II and only 15% of the patients in Group III. The frequency of rescue analgesic among the three groups was comparable except at 0.5 hours. 50% of patients showed complete response in Group III, as compared to 30% and 20% in Group I and Group II respectively. Conclusion: The combined regimen of ondansetron with dexamethasone was more efficacious as an antiemetic in controlling postoperative nausea and vomiting in children undergoing tonsillectomy.

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Postoperative nausea and vomiting , dexamethasone , ondansetron , tonsillectomy

Cumhuriyet Medical Journal

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