Kertmen, Neyran Ministry of Health - Internal Medicine Clinic, Dışkapı Yıldırım Beyazıt Education And Research Hospital, Turkey , Yıldız, Mehmet Ministry of Health - Internal Medicine Clinic, Dışkapı Yıldırım Beyazıt Education And Research Hospital, Turkey

Does Type II diabetes mellitus affect bone turn-over markers in premenopausal women? A single center experience

33502

Objective: Diabetes mellitus (DM) is known to cause osteoporosis in premenopausal women with type II DM. The aim of this study was to show changes in bone turnover markers in diabetic premenopausal women. Methods: Ninety-two women treated for type 2 DM and a control group of 33 women without diabetes were evaluated in terms of bone mineral density, osteocalcin, c-terminal telopeptide of type I collagen and homocysteine levels. Demographic data including body mass index, age and smoking status were recorded in both the patient and control groups. DM regulation was classified according to the European Association for the Study of Diabetes database (EASD). Results: Age, BMI, smoking and duration of disease did not affect BMD or bone turnover markers. When the treatment modalities were evaluated, laboratory analysis revealed abnormal osteocalcin levels in patients using oral antidiabetics (p= 0.006). Homocysteine levels were abnormal in the diabetic group compared to the control group (p=0.018). Conclusion: Our results demonstrate that DM adversely affected femoral BMD and bone turnover markers such as homocysteine. Some DM pharmacotherapies have side-effects on markers such as osteocalcin. Although some reports in the literature have suggested that the regulation of DM may affect the risk of osteoporosis, our results do not support that idea.

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Osteoporosis , Type 2 Diabetes Mellitus , bone turnover markers , bone densitometry

Cumhuriyet Medical Journal

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