مرکز منطقه ای اطلاع رساني علوم و فناوري

Abstract :

Objective: Polymicrogyria (PMG) is the most common malformation of the brain cortex. There isan impaired migration and proliferation of neuronal cells leading to a thickened cortex with multiplesmall (micro) gyri. It can be focal or diffuse. The aim of this study is to delineate the MRI propertiesof an aberrant fissure (AF) associated with PMG. Method: MR images of 34 patients were retrospectively investigated for the features of PMG, the presence of an AF and its properties along with the clinical findings. Results: Thirty-one patients (91.2%) showed focal PMG, whereas 3 patients (8.8%) had diffuse involvement of the brain. None of the diffuse PMGs showed an AF, whereas 30 patients (88%) with focal PMG showed an associated AF. Only one patient with a focal PMG did not display an AF, however, he had an arachnoid cyst adjacent to the PMG. AFs were related to or in continuity with major fissures of the brain in 27 subjects. Conclusions: An AF is present in the vast majority of patients with a focal PMG, however, there is no significant relation between the presence of AF and clinical findings.