Abstract :
Objective: It was observed that inflammation plays an important role in the progress of atherosclerotic vascular disease. This study is intended to indicate that, in oxidative andinflammatory medium, the course of the atherosclerotic process can be determined by the imbalance between Interleukin-12 (IL-12) and Transforming Growth Factor-beta1 (TGF-β1) with a view to evaluate the effects of proinflammatory and anti-inflammatory cytokines on the course of the atherosclerotic coronary artery disease. Method: 80 patients, who applied to cardiology outpatient clinic for typical chest pain, to whom coronary angiography was applied upon the detection of ischemia as a result of the effort test or myocardial perfusion scintigraphy conducted, and each of whom is exposed to at least one traditional risk factor for atherosclerotic coronary artery disease, were included to the study. Findings: The patients were split into three groups as those, in whom atherosclerosis was not detected, those, for whom atherosclerosis prevalence is low, and those, for whom atherosclerosis level is high, according to the CASS 20 scores. It was observed that, as the atherosclerosis prevalence increased; average serum IL-12 levels (3,33±0,15 / 9,70±0,22 / 23,60±0,46 pg/ml) increased while average serum TGF-β1 levels, (32,1±0,59 / 18±0,28 / 6,74±0,42 ng/ml), decreased. Conclusion: It was indicated that, in oxidative and inflammatory medium, the course of the atherosclerotic coronary artery disease was determined by the dominant cytokine on the intima of the related vascular segment.
NaturalLanguageKeyword :
IL , 12 , TGF , β1 , atherosclerosis
