Author/Authors :
mercan, sevcan ondokuz mayıs üniversitesi - fen edebiyat fakültesi - biyoloji bölümü, Samsun, turkey , eren, banu ondokuz mayıs üniversitesi - fen edebiyat fakültesi - biyoloji bölümü, Samsun, Turkey , dinç, nazan ondokuz mayıs üniversitesi - fen edebiyat fakültesi - biyoloji bölümü, Samsun, turkey
Title Of Article :
Investigation of curcumin’s antioxidant effect on pesticide chlorpyrifos caused damage in rat (Wistar albino) liver
Abstract :
In this study, broad-spectrum pesticide chlorpyrifos (CPF) caused damage on rat (Wistar albino) liver and protective role of curcumin, a well known antioxidant were investigated. For this purpose, 4 groups were created, including a control group with 3 treatment groups; only CPF, only curcumin and CPF + curcumin, respectively. Each group was consisted of 12 male rats. 5 mg/kg/day CPF and 100 mg/kg/day curcumin were given to the animals via gavage. 6 animals in each group were sacrificed in 15th and 30th days. Following histologic examinations, when the CPF group compared with the control group; hydropic degenerations, focal inflammatory cell infiltration, expansion in the sinusoidal, cytoplasmic changes in hepatocytes and glycogen concentration differences were observed by light microscopic evaluations. It was observed that CPF + curcumin-treated group had histological changes than CPF group. The results showed that curcumin has a reduction effects on CPF induced histopathological damage.
NaturalLanguageKeyword :
Histological changes. Liver. Chlorpyrifos. Curcumin
JournalTitle :
Anadolu Journal Of Agricultural Sciences
