Author/Authors
mercan, sevcan ondokuz mayıs üniversitesi - fen edebiyat fakültesi - biyoloji bölümü, Samsun, turkey , eren, banu ondokuz mayıs üniversitesi - fen edebiyat fakültesi - biyoloji bölümü, Samsun, Turkey , dinç, nazan ondokuz mayıs üniversitesi - fen edebiyat fakültesi - biyoloji bölümü, Samsun, turkey
Title Of Article
Investigation of curcumin’s antioxidant effect on pesticide chlorpyrifos caused damage in rat (Wistar albino) liver
شماره ركورد
34002
Abstract
In this study, broad-spectrum pesticide chlorpyrifos (CPF) caused damage on rat (Wistar albino) liver and protective role of curcumin, a well known antioxidant were investigated. For this purpose, 4 groups were created, including a control group with 3 treatment groups; only CPF, only curcumin and CPF + curcumin, respectively. Each group was consisted of 12 male rats. 5 mg/kg/day CPF and 100 mg/kg/day curcumin were given to the animals via gavage. 6 animals in each group were sacrificed in 15th and 30th days. Following histologic examinations, when the CPF group compared with the control group; hydropic degenerations, focal inflammatory cell infiltration, expansion in the sinusoidal, cytoplasmic changes in hepatocytes and glycogen concentration differences were observed by light microscopic evaluations. It was observed that CPF + curcumin-treated group had histological changes than CPF group. The results showed that curcumin has a reduction effects on CPF induced histopathological damage.
From Page
132
NaturalLanguageKeyword
Histological changes. Liver. Chlorpyrifos. Curcumin
JournalTitle
Anadolu Journal Of Agricultural Sciences
To Page
138
JournalTitle
Anadolu Journal Of Agricultural Sciences
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