Author/Authors :
kizişar, dilay middle east technical university - department of chemistry, Turkey , subaşi, n. tuna middle east technical university - department of chemistry, Turkey , eröksüz, serap middle east technical university - department of chemistry, Turkey , demir, ayhan s. middle east technical university - department of chemistry, Turkey , mert, olcay middle east technical university - department of chemistry, turkey , mert, olcay kocaeli university - department of chemistry, Turkey
Abstract :
Syntheses of biodegradable PSA:PEG copolymers for the formation of nano and micro carriers were performed. Camptothecin (CPT) was selected as an anti-cancer drug. CPT can easily hydrolyze at physiological conditions (pH=7.4). This causes the loss of its activity, and it turns into inactive toxic carboxylate form from active lactone state. To keep anti cancer drug in the lactone form, it was efficiently loaded into PSA:PEG nanoparticles and microparticles, and the stability of CPT in the carriers was fully examined with HPLC. It was found that the drug was highly stable in active form in the prepared nano and microcarriers ( 95 %). Particles were imaged with confocal, SEM, and optic microscopes.
NaturalLanguageKeyword :
Camptothecin , PSA , PEG , Stability , Nanoparticles
