Author/Authors :
ÖZSOY, Şule Yurdagül Mustafa Kemal University - Faculty of Veterinary Medicine - Department of Pathology, Turkey , ÖZYILDIZ, Zafer Harran University - Faculty of Veterinary Medicine - Department of Pathology, Turkey , GÜZEL, Murat Mustafa Kemal University - Faculty of Veterinary Medicine - Department of Internal Medicine, Turkey
Title Of Article :
Clinical, pathological and immunohistochemical findings of bovine cutaneous papillomatosis
Abstract :
Bovine cutaneous papillomatosis caused by a bovine papillomavirus, is a common skin disease in Turkey. The aim of the present study was to describe the clinical, histopathological and immunohistochemical aspects of naturally occurring bovine cutaneous papillomatosis. A total of 82 Holstein cattle (9.5%), aged between 5 and 24 months, were diagnosed as cutaneous papilloma by clinical examination. The percentage of papilloma and papillomatosis in male and female was found in 7.3% and 14.8%, respectively. The cauliflower-like growths of varying sizes (0.5-11 cm) were mostly located on the head (63.2%). Histopathology revealed various degrees of acanthosis and hyperkeratosis in all neoplasms. Immunohistochemical (IHC) examination with antibodies against proliferating cell nuclear antigen (PCNA) and Ki-67 were detected in the basal layer of the epidermis and connective tissue. Bovine papillomavirus (BPV-1) antigens were detected in the basal layer. In conclusion, it was decided that the BPV-1, PCNA and Ki-67 antibodies were very useful markers in the diagnosis of bovine cutaneous papilloma.
NaturalLanguageKeyword :
Bovine papillomatosis , BPV , 1 , Ki , 67 , PCNA
JournalTitle :
Veterinary Journal of Ankara University
