DEDE, Fuat Marmara Universitesi - Tıp Fakültesi - Nüklear Tıp Anabilim Dalı, Turkey , ÖNEŞ, Tunç Marmara Universitesi - Tıp Fakültesi - Nüklear Tıp Anabilim Dalı, Turkey , CANDEMİR, Sinem Marmara Universitesi - Tıp Fakültesi - Nüklear Tıp Anabilim Dalı, Turkey , NOVRUZOV, Fuad Marmara Universitesi - Tıp Fakültesi - Nüklear Tıp Anabilim Dalı, Turkey , GÜNGÖR, Serkan Marmara Universitesi - Tıp Fakültesi - Nüklear Tıp Anabilim Dalı, Turkey , ARAS, Mustafa Marmara Universitesi - Tıp Fakültesi - Nüklear Tıp Anabilim Dalı, Turkey , ÖZGÜVEN, Salih Marmara Universitesi - Tıp Fakültesi - Nüklear Tıp Anabilim Dalı, Turkey , İNANIR, Sabahat Marmara Universitesi - Tıp Fakültesi - Nüklear Tıp Anabilim Dalı, Turkey , ERDİL, Tanju Yusuf Marmara Universitesi - Tıp Fakültesi - Nüklear Tıp Anabilim Dalı, Turkey , TUROĞLU, Halil Turgut Marmara Universitesi - Tıp Fakültesi - Nüklear Tıp Anabilim Dalı, Turkey

Comparison of Fixed 10 mCi and 15 mCi Iodine-131 Doses for the Treatment of Graves’ Disease: 11 Year Study

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Objectives: Fixed dose Iodine-131 (RAI) treatment is a simple method which does not obviate sophisticated calculations. In this study, we compared the results of fixed 10mCi and 15 mCi RAI treatment. Patients and Methods: In this study we included 55 patients who received fixed 10 mCi and 15 mCi RAI treatment between 1997-2008 years and were followed for at least 2 years. Then we analyzed the results as successful (euthyroid, hypothyroid) and unsuccessful (persistant hyperthyroid) treatment rates and other parameters that could have affected the results. Results: The success rate in patients who received 10 mCi RAI was 87% (euthyroid 9.1%, hypothyroid 78.2%). The success rate in patients who received 15 mCi RAI was 100% (hypothyroid). There is no statistically significant difference between these groups except mean propythiouracil doses (10 mCi: 190 mg, 15 mCi: 350 mg, p 0.05). Conclusion: Fixed 10 mCi and 15 mCi RAI dose applications were both successful in the treatment of Graves’ disease. Albeit at a lower rate persistent hyperthyroidism can be seen in patients given fixed 10 mCi RAI dose.

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Graves disease , Therapy , Fixed dose , Iodine , 131

Marmara Medical Journal

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