Alcelik, Aytekin Abant İzzet Baysal University - İzzet Baysal Medical Faculty - Department of Internal Medicine, Turkey , Aytekin, Eyup Abant İzzet Baysal University - İzzet Baysal Medical Faculty - Department of Internal Medicine, Turkey , Tosun, Mehmet Abant İzzet Baysal University - İzzet Baysal Medical Faculty - Department of Biochemistry, Turkey , Aktaş, Gülali Abant İzzet Baysal University - İzzet Baysal Medical Faculty - Department of Internal Medicine, Turkey , Ayhan, Selim Abant İzzet Baysal University - İzzet Baysal Medical Faculty - Department of Cardiology, Turkey , Ozturk, Serkan Abant İzzet Baysal University - İzzet Baysal Medical Faculty - Department of Cardiology, Turkey , Ozlu, Mehmet Fatih Abant İzzet Baysal University - İzzet Baysal Medical Faculty - Department of Cardiology, Turkey , Savli, Haluk Abant İzzet Baysal University - İzzet Baysal Medical Faculty - Department of Internal Medicine, Turkey , Yazici, Mehmet Abant İzzet Baysal University - İzzet Baysal Medical Faculty - Department of Cardiology, Turkey

N-terminal pro-B-type natriuretic peptide and insulin resistance in overweight and obese subjects

37966

Several studies have been conducted to investigate B-type natriuretic peptide (BNP) levels in different obese populations. However, in these studies BNP levels were lower in obese population with an unclear mechanism which has not been explained yet. We sought to investigate the relationship among plasma NT-proBNP levels, obesity and insulin resistance in subjects with no known heart disease. The study population consists of two groups. Subjects with a body mass indexs (BMI) of ≤25 kg/m2 were classified as lean group (LG, n=30), BMI of 25 kg/m2 were classified as overweight and obese group (OG, n=78). Severe hypertension, heart failure, ischemic heart disease, renal or hepatic insufficiency, age 65, pregnancy and malignancy were excluded. There was a negative correlation between NT-proBNP and weight (r=-0.379, p=0.004) and BMI (r=-0.286, p=0.030) in LG, but there was no such reverse correlation between NT-proBNP and BMI (r=-0.057, p=0.463) in OG. We performed multivariable logistic regression analyses to examine predictors of obesity levels. There were not any significant relation between these predictors and obesity. Insulin levels had a strong association with obesity level however this association was still insignificant (p=0.054). In LG group, there was a negative correlation between NT-proBNP and BMI. There was no correlation between NT-proBNP and homeostatic model assessment (HOMA) and insulin levels (r=-0.035, p=0.789) in LG group, but there was a statistically significant negative correlation between BNP and HOMA (r=-0.219, p=0.009) and insulin levels (r=-0.252, p=0.002) in OG group. Race and ethnicity may contribute this association.

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NT , proBNP , Obesity , Insulin resistance , Body mass index , Overweight , Waist circumference

Journal Of Experimental an‎d Clinical Medicine

182