Bagci, Binnur Cumhuriyet University - Faculty of Health Sciences, Advanced Technology Research Center - Department of Nutrition and Dietetics, Turkey , Arslan, Sulhattin Cumhuriyet University - Faculty of Medicine - Department of Chest Diseases, Turkey , Kurtulgan, Hande Kucuk Cumhuriyet University - Faculty of Medicine - Department of Medical Genetics, Turkey , Sezgin, Ilhan Cumhuriyet University - Faculty of Medicine - Department of Medical Genetics, Turkey , Yildirim, Malik Ejder Cumhuriyet University - Faculty of Medicine - Department of Medical Genetics, Turkey , Bagci, Gokhan Cumhuriyet University - Faculty of Medicine - Department of Medical Genetics, Turkey

MCP-1-2518 A G and CCR2 V64I polymorphisms in Turkish patients with lung cancer

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In the current study, we aimed to investigate the possible role of MCP-1 -2518 A G and CC chemokine receptor 2 (CCR2) V64I polymorphisms in patients with lung cancer. Sixty-five patients with lung cancer (57 with NSCLC and 8 with SCLC) and 57 healthy controls were enrolled. Polymerase chain reactionrestriction fragment length polymorphism (PCR-RFLP) method was used. Genotype distribution of monocyte chemoattractant protein 1 (MCP-1) -2518 A G polymorphism in lung cancer patients was as follows: 30 for AA, 30 for AG and 5 for GG genotype. Frequency of minor G allele in patients and controls were found as 30.8% and 23.7%, respectively. In patients, genotype distribution of CCR2 V64I polymorphism was as follows: 47 for GG, 16 for GA, and 2 for AA. Frequency of minor A allele was found in patients and controls as 15.4% and 19.2%, respectively. Genotype distribution and allele frequencies of MCP-1 and CCR2 polymorphism were not statistically different between patients and controls (p values 0.05 for both polymorphisms). In lung cancer patients, there was no significant association between smoking status and MCP-1 and CCR2 polymorphisms. Similarly, no significant association was found between distant organ metastasis and both gene polymorphisms. Our findings suggest that MCP-1 -2518 A G and CCR2 V64I polymorphisms are not associated with genetic susceptibility to lung cancer and lung cancer metastasis.

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CC chemokine receptor 2 , Chemokine , Lung cancer , Monocyte chemoattractant protein 1 , Polymorphism

Journal Of Experimental an‎d Clinical Medicine

84