Author/Authors
Atalay, Yunus Oktay Ondokuz Mayis University - Department of Radiology, Outpatient Anesthesia Service, Turkey , Umuroglu, Tumay Marmara University - Department of Anesthesiology and Reanimation, Turkey , Yagmur, Caglayan Ondokuz Mayis University - Department of Plastic and Reconstructive Surgery, Turkey , Gogus, Fevzi Yilmaz Academic Hospital - Department of Anesthesiology, Turkey , Bozkurt, Suheyla Marmara University - Department of Pathology, Turkey
Title Of Article
The comparative effects of local anaesthetics on wound healing in rats: Bupivacaine vs Levobupivacaine
شماره ركورد
38250
Abstract
The aim of this study is to investigate the effects of local anaesthetic agents (bupivacaine and levobupivacaine) on wound healing in rats. Wistar albino rats were randomly assigned to three groups (n=10 per group); the control group, the bupivacaine group, and the levobupivacaine group. An incision measuring 5 cm in length was made over the dorsum in all groups. The incisions were infiltrated with 3 ml of normal saline in the control group, 3 ml of 0.25% bupivacaine in the bupivacaine group, and 3 ml of 0.25% levobupivacaine in the levobupivacaine group. Histopathological examinations and tensile strength measurements were performed on tissue samples taken from the incision line 14 days after infiltration. Epidermal and dermal regeneration scores were significantly lower in the levobupivacaine group compared with the bupivacaine and control groups (p 0.05). Granulation tissue thickness, angiogenesis, and tensile strength measurements were not significantly different between groups. Even though incomplete epidermal and dermal regeneration scores were attained using levobupivacaine, both bupivacaine and levobupivacaine had no negative effects on the overall clinical wound-healing process.
From Page
93
NaturalLanguageKeyword
Bupivacaine , Infiltration anaesthesia , Levobupivacaine , Local anaesthetics , Wound healing
JournalTitle
Journal Of Experimental and Clinical Medicine
To Page
98
JournalTitle
Journal Of Experimental and Clinical Medicine
Link To Document