Author/Authors
kaya, emre firat üniversitesi - veteriner fakültesi - biyokimya anabilim dali, Elazig, turkey , yilmaz, seval firat üniversitesi - veteriner fakültesi - biyokimya anabilim dali, Elazig, turkey
Title Of Article
Determination of Effects of Nigella Sativa Oil on Doxorubicin-Induced Cardiotoxicity in Rats
شماره ركورد
41892
Abstract
This study was carried out to determine the effects of nigella sativa oil on the doxorubicin (DOX) cardiotoxicity in rats. In the study, rats were divided into 4 groups: Group 1: Control group, Group 2: Nigella sativa oil-treated group (2 mL/kg/day gavage, 7 days), Group 3: DOX-treated group (20 mg/kg body weight, single dose, i.p.), and Group 4: DOX (20 mg/kg body weight, single dose, i.p.) + nigella sativa oil (2 mL/kg/day gavage, 7 days) treated group. Nigella sativa application was started 2 days before DOX application and continued for 7 days. At the end of the study, malondialdehyde (MDA), reduced-glutathione (GSH) levels, and antioxidant enzymes activities such as catalase (CAT), glutathione peroxidase (GSH-Px), superoxide dismutase (SOD), and glutathione-S- transferase (GST) were determined. In the DOX-treated group, there was an increase in MDA (P 0.001) and GSH (P 0.001) levels, and a decrease in CAT (P 0.001), GSH-Px (P=0.024), and GST (P 0.001) activities compared to the control group. There was no statistically significant difference in SOD activity. MDA, GSH levels and CAT, GSH-Px and GST activities were found to be reached to the values of control group in the DOX+nigella sativa treated group compared to the DOX-treated group. As a result, Nigella sativa oil has been shown to protect heart tissue against oxidative damage caused by DOX, a potent chemotherapeutic drug.
From Page
31
NaturalLanguageKeyword
Doxorubicin , nigella sativa oil , malondialdehyde , antioxidant
JournalTitle
Fırat University Veterinary Journal Of Health Sciences
To Page
36
JournalTitle
Fırat University Veterinary Journal Of Health Sciences
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