Author/Authors
ÖZDEMIR, Ahmet Anadolu University - Faculty of Pharmacy - Department of Pharmaceutical Chemistry, Turkey , KAPLANCIKLI, Zafer AsIm Anadolu University - Faculty of Pharmacy - Department of Pharmaceutical Chemistry, Turkey , TURAN-ZITOUNI, Gülhan Anadolu University - Faculty of Pharmacy - Department of Pharmaceutical Chemistry, Turkey , ALTINTOP, Mehlika Dilek Anadolu University - Department of Pharmaceutical Chemistry - Faculty of Pharmacy, Turkey , DEMIRCI, Fatih Anadolu University - Faculty of Pharmacy - Department of Pharmacognosy, Turkey
Title Of Article
SYNTHESIS OF SOME N-(BENZOTHIAZOL-2-YL)-2-(4H-[1,2,4]TRIAZOL -3-YLSULFANYL)ACETAMIDES AND THEIR ANTIMICROBIAL ACTIVITY
شماره ركورد
41963
Abstract
The aim of this study is to synthesize novel benzothiazolyl-amide derivatives and investigate their antimicrobial activities. N-(Benzothiazol-2-yl)-2-(4H-[1,2,4]triazol-3-ylsulfanyl) acetamide derivatives (3a-j) were prepared by the reaction of N-(benzothiazol-2-yl)-2-chloroacetamides (1a-e) with appropriate 4H-[1,2,4]triazol-2-thione (2a-b). The chemical structures of the compounds were elucidated by elemental analyses, IR, 1H-NMR, 13C-NMR and FAB+-MS spectral data. Their antimicrobial activities against Escherichia coli (NRRL B-3008), Staphylococcus aureus (ATCC 6538), Pseudomonas aeruginosa (ATCC 27853), Proteus vulgaris (NRRL B-123), Salmonella typhimurium (ATCC 13311), Methicillin-resistant Staphylococcus aureus (MRSA) (clinic isolate), Candida albicans (NRRL Y-12983) and Candida parapsilosis (NRRL Y-12696) were investigated. The results showed that all of the tested compounds were inactive against the test organisms.
From Page
145
NaturalLanguageKeyword
Benzothiazole , Triazole , Antimicrobial activity
JournalTitle
Anadolu University Journal of Science and Technology C - Life Sciences and Biotechnology
To Page
151
JournalTitle
Anadolu University Journal of Science and Technology C - Life Sciences and Biotechnology
Link To Document