Author/Authors
altintop, mehlika dilek anadolu university - faculty of pharmacy - department of pharmaceutical chemistry, Turkey , sever, belgin anadolu university - faculty of pharmacy - department of pharmaceutical chemistry, Turkey , özdemir, ahmet anadolu university - faculty of pharmacy - department of pharmaceutical chemistry, Turkey , kaplancikli, zafer asim anadolu university - faculty of pharmacy - department of pharmaceutical chemistry, Turkey
Title Of Article
SYNTHESIS AND EVALUATION OF BENZODIOXOLE APPENDED PYRAZOLINE DERIVATIVES AS NEW ANTIMICROBIAL AGENTS
شماره ركورد
41988
Abstract
In the current work, new pyrazoline derivatives were synthesized via the reaction of 1- (chloroacetyl)-3-(2-thienyl)-5-(3,4-methylenedioxyphenyl)-2-pyrazoline with sodium salts of N,Ndisubstituted dithiocarbamic acids. The compounds were investigated for their inhibitory effects on pathogenic bacteria and yeasts using broth microdilution method. MTT assay was carried out to determine the cytotoxic effects of the compounds on NIH/3T3 mouse embryonic fibroblast cell line. Among the tested compounds, 1-[[(4-(4-fluorophenyl)piperazin-1-yl)thiocarbamoylthio]acetyl]-3-(2- thienyl)-5-(3,4-methylendioxyphenyl)-2-pyrazoline (2) was found to be the most promising antimicrobial agent due to its notable inhibitory effects on Klebsiella pneumoniae, Pseudomonas aeruginosa, Escherichia coli and Candida parapsilosis when compared with the reference agents. Compound 2 did not cause any toxicity against NIH/3T3 cell line. This outcome pointed out that the antimicrobial activity of compound 2 was selective.
From Page
1
NaturalLanguageKeyword
Benzodioxole , Dithiocarbamate , Pyrazoline , Antimicrobial activity , Cytotoxicity
JournalTitle
Anadolu University Journal of Science and Technology C - Life Sciences and Biotechnology
To Page
11
JournalTitle
Anadolu University Journal of Science and Technology C - Life Sciences and Biotechnology
Link To Document