Author/Authors
TEKEDERELI, Ibrahim University of Texas - MD Anderson Cancer Center - Department of Experimental Therapeutics, USA , KARA, Murat Firat University - Faculty of Medicine - Department of Medical Genetics, Turkey , NAMLI, Mustafa N. Elazig Mental Health Hospital - Department of Psychiatry, Turkey , OZER, Ali Inonu University - Faculty of Medicine - Department Public Health, Turkey , CANATAN, Halit Erciyes University - Faculty of Medicine - Department of Medical Biology, Turkey , AKYOL, Omer University of Hacettepe - Faculty of Medicine - Department of Biochemistry and Clinical Biochemistry, Turkey , ELYAS, Halit M. Firat University - Faculty of Medicine - Department of Medical Biology, Turkey , YUCE, Huseyin Firat University - Faculty of Medicine - Department of Medical Genetics, Turkey
Title Of Article
Lack of Association between Glutathione Peroxidase 1 (pro197leu) Polymorphism and Cchizophrenia in a Turkish Population
شماره ركورد
42020
Abstract
Introduction: Schizophrenia is a complex disease characterized with psychosis, cognitive dysfunction and negative symptoms. The etiology is unknown in most cases. Free radicals and antioxidant system balance shifting in favor of oxidants resulted from oxidative stress has been accounted for in the pathogenesis of schizophrenia. In this study, we aimed to elucidate the role of the pro197leu polymorphism of glutathione peroxidase 1 (GPX1) enzyme, the major subunit of glutathione peroxidase, in the etiopathogenesis of schizophrenia. Materials and Methods: The study group was composed of 100 patients (54 males and 46 females) and 100 healthy volunteers (66 males and 34 females). The study was conducted using the PCRRFLP method. Results: The allele frequencies of pro197 and leu197 variants of GPX1 were similar in the control group and schizophrenic patients (p=0.318). Distributions of the genotype frequencies were similar between the controls and patients (p=0.402), as well as males and females in patient group (p=0.225). Conclusion: The pro197leu polymorphism of GPX1 gene may not constitute any susceptibility for schizophrenia in Turkish population studied.
From Page
48
NaturalLanguageKeyword
Glutathione Peroxidase 1 , Polymorphism , Schizophrenia
JournalTitle
Kocatepe Medical Journal
To Page
53
JournalTitle
Kocatepe Medical Journal
Link To Document