Platelet Rich Plasma Therapy in Musculoskeletal System Injuries

42054

Musculoskeletal system injuries are the most common cause of long term severe pain and physical disability and affect hundred millions worldwide. St udies concerning wound healing demonstrated that, growth factors have a complex interaction in normal tissue structure and in response to tissue damage, furthermore they play a crucial and effective role in tissue regeneration. Platelets have important role in coagulation cascade, however it has also been proven that, they contain growth factors that play a central role in tissue regeneration. The aim of platelet rich plasma (PRP) therapy is to accelerate wound healing and improve functional restoration by using supraphysiological doses of growth factors in concentrated platelets. PRP therapy, now being used in various musculoskeletal conditions such as lateral epicondilitis, achilles tendinitis, rotator cuff lesions, ligament ruptures, muscle strains, osteoarthritis, is particularly in interest of fields like orthopedics, physical medicine and rehabilitation and sports medicine, but also dentistry, plastic surgery, dermatology, neurology and ophtalmology. There is lack of standardization of this new therapy modality. There are various kind of commercial kits which may produce different PRP’s causing difficulties in evaluating the results of clinical studies. However there are promising results in clinical studies assesing the effect of PRP’s. The target of new therapies is to obtain predictable, rapid tissue regeneration and functional improvement. In this context, PRP serves as an important step.

51

Musculoskeletal system injuries , platelet rich plasma , wound healing.

Kocatepe Medical Journal

59

Kocatepe Medical Journal