Additive Effect of Hypertension to Inflammation Reaction in Coronary Artery Patients

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Objective: Investigation about an additional contribution of hypertension (HT) to inflammatory process in stable coronary artery disease (CAD). Material and Methods: Patients were divided into three groups . Group I only with CAD, Group II generated with patients with HT in addition to the CAD. The control group was created with healthy volunteers of similar age group. hs-CRP, IL-1β, IL-6, IL-10 and TNF-α levels were measured. Results: When hs-CRP levels are compared the value of hs-CRP in patients with CAD was found to be significantly increased (HR: 1.4 ± 0.8 mg / L , control: 0.7 ± 0.6 mg / L , p 0.01). When the patients with HT in addition to the CAD and the patients in control group are compared , the value of hs-CRP were significantly increased in the group of CAD+HT (CAD+HT: 1.9 ± 1.2 mg / L, Control: 0.7 ± 0.6 mg /L, p 0.001 ). When the TNF-α and IL-1β levels between the CAD group and the control group are compared TNF-α and IL-1β levels in patients with CAD was found to have significantly increased TNF-α value. However, IL-10 levels were not different between groups. Conclusion: Even if it is stable, the inflammatory response in patients with CAD was significantly higher than that in the control group. HT demonstrated an additive effect on the inflammatory process.

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Coronary artery disease , stabil angina , inflammatory markers

Kocatepe Medical Journal

134

Kocatepe Medical Journal