Association Analysis of the BDNF Val66Met Variation with Obesity in a Population from Turkey: A Case Control Study

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Objective: Obesity is becoming the epidemic health problem worldwide with a very complex etiology. The interaction between diverse genetic and environmental factors contributes to development of obesity. In this tudy, it was aimed to investigate the association/s between BDNF gene Val66Met variant and obesity as well as obesity-related clinical phenotypes in a population from Turkey. Material and Methods: A total of 168 subjects (88 obese cases and 80 non-obese healthy controls) were included in this study. Following the clinical evalution, the subjects were assessed for anthropometric measurement and body composition analyses. Genotyping of BDNF Val66Met polymorphism was carried out using polymerase chain reaction-restriction fragment length polymorphism technique. Then the genotypic and allele frequencies as well as anthropometric measurement were analyzed statisitically using SPSS program. Results: The results revealed no significant difference between BDNF Val66Met polymorphism and obesity or obesity-related clinical phenotypes in ceses versus controls. Conclusion: These results do not support a predisposing role of BDNF Val66Met polymorphism in the developemnt of obesity or obesity realted clinical phenotypes. However, to confirm that the gene variant contributes to obesity and obesity-related phenotypes, further studies with both higher population sizes and many candidate genes are needed to be investigated simultaneously.

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Obesity , brain , derived neurotrophic factor Val66Met polimorphism , association

Kocatepe Medical Journal

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Kocatepe Medical Journal