Author/Authors
ÖTER, Serdar Eskişehir Osmangazi Üniversitesi - Tıp Fakültesi - Genel Cerrahi AD, Türkiye , ŞAHİN, Adnan Eskişehir Osmangazi Üniversitesi - Tıp Fakültesi - Genel Cerrahi AD, Türkiye , BURUKOĞLU, Dilek Eskişehir Osmangazi Üniversitesi - Tıp Fakültesi - Histoloji AD, Türkiye , SUTKEN, Emine Eskişehir Osmangazi Üniversitesi - Tıp Fakültesi - Biyokimya AD, Türkiye
Title Of Article
The Effects Of Erythropoietin On Liver Tissue In An Experimental Rat Model Of Septic Shock
شماره ركورد
42213
Abstract
Background: Sepsis is a systemic response that develops against infection and inflammation. These disorders remain the most important cause of mortality in intensive care units. Materal-Methods: In the present study, we used an experimental model of sepsis and septic shock by cecal ligation and perforation in rats to investigate the effects of erythropoetin on hepatic functions and liver histology. Findings: After treatment, we found statistically significant improvement in AST and ALT values at Erythropoietin treatment group. Also statistically significant improvements were observed in histological findings of liver in rats treated with erythropoetin. Results: In this study, we used erythropoietin to treat the septic shock and ischemia-perfusion injury and inflammation. Data suggest that erythropoetin for the treatment of septic shock, as well as the liver damage resulting from the septic shock. Results of this study should prompt future clinical studies. It seems likely that erythropoetin protects the organs against sepsis-induced oxidative organ injury.
From Page
178
NaturalLanguageKeyword
erythropoetin , sepsis , rat , liver
JournalTitle
Kocatepe Medical Journal
To Page
184
JournalTitle
Kocatepe Medical Journal
Link To Document