Author/Authors
keleş, ibrahim afyonkarahisar sağlık bilimleri üniversitesi - tıp fakültesi - üroloji anabilim dalı, Turkey , bozkurt, mehmet fatih afyon kocatepe üniversitesi - veteriner fakültesi - patoloji anabilim dalı, Turkey , fidan, abdurrahman fatih afyon kocatepe üniversitesi - veteriner fakültesi - biyokimya anabiim dalı, Turkey , karalar, mustafa afyonkarahisar sağlık bilimleri üniversitesi - tıp fakültesi - üroloji anabilim dalı, Turkey , çoban, soner sağlık bilimleri üniversitesi - şevket yılmaz eğitim ve araştırma hastanesi, üroloji kliniği, Turkey , denk, barış afyon kocatepe üniversitesi - veteriner fakültesi - biyokimya anabiim dalı, Turkey
Title Of Article
PROTECTIVE EFFECTTS OF DANTROLENE AGAINST SPINAL CORD INJURY INDUCED EARLY OXIDATIVE DAMAGEIN RABBIT BLADDER
شماره ركورد
42349
Abstract
OBJECTIVE: To investigate the effects of early dantrolene treatment of changes in bladder characteristics after spinal cord injury (SCI). MATERIAL AND METHODS: We studied the possible protective effects of dantrolene on SCI- induced oxidative damage in bladder tissues of rabbit. We devided 38 rabbits into five groups; the control group (1), spinal cord injury (SCI) (2.group), SCI+dantrolene 0. Hour (3.group), SCI +dantrolene 1. Hour (4.group), SCI+dantrolene 4. Hour (5.group). After a 24 hour euthanasia the urinary bladder was removed for gross, histological and biochemical evaluation. Bladder tissues were investigated by light microscopy. Furthermore blood and tissue malondialdehyde (MDA), glutathione (GSH) and nitric oxide (NO) were also determined. RESULTS: Significant increase in congestion and edema was observed in the early period spinal trauma (SCI) group compared to control group. In groups 3 and 4, dantrolene was more effective in preventing edema and inflammation, whereas in groups 3, 4 and 5, dantrolene did not reduce congestion. MDA levels and NO levels increased and GSH levels were decreased in SCI group compared to controls. Dantrolene was not effective in all three treatment groups to normalize decreased GSH levels after trauma. It was seen that dantrolene was not effective in all three treatment groups to normalize the decreased GSH level after trauma. Increased levels of MDA after spinal trauma were found to be the lowest in group 5 given at the 4th hour of dantrolene. CONCLUSIONS: It can be concluded that dantrolene given in the early period is effective in reducing inflammation and edema in the bladder and not effective in decreasing post-traumatic GSH levels to normal. As a result; dantrolene may be helpful in correcting impaired bladder morphology.
From Page
195
NaturalLanguageKeyword
Spinal cord injury , Dantrolene , Anti , inflammatory , Antioxidant
JournalTitle
Kocatepe Medical Journal
To Page
200
JournalTitle
Kocatepe Medical Journal
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