RADIOFREQUENCY THERMAL ABLATION FOR TREATMENT OF CYCTIC ECHINOCOCCOSIS: AN EX- VIVO EXPERIMENTAL STUDY IN ANIMAL MODELS

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OBJECTIVE: Radiofrequency thermal ablation (RTA) is a minimally invasive technique often used in inoperable patients with other comorbidities. The aim of the ex-vivo study was to evaluate the efficacy of different temperatures and durations of RTA for treatment of lung cystic echinococcosis in animal models (explanted organs). MATERIAL AND METHODS: Infected lungs from 45 slaughtered bovines were collected. Live pulmonary cysts were randomly divided into three main following radiofrequency treatment groups according to the heat. Group 1 (n=15) at 90 °C, group 2 (n=15) at 100 °C, and group 3 (n=15) at 110 °C. Then the groups were divided into three sub-groups according to duration of radiofrequency application (7 minute n= 5; 9 minute n=5; and 11 minute n=5). After treatment, all cysts were sectioned and examined by histology. Cysts were defined as alive if a preserved germinal layer at histology was evident, and as successfully treated if the germinal membrane was necrotic. RESULTS: Following RTA application, 41 of 45 samples consisted of partial necrotic sections of the germinal membrane defined as alive. Only 4 of 5 samples with completely necrotic germinal membrane defined as successfully treated in 11 minute 110 °C group. The destruction rate has a positive correlation with heat of RTA application (Phi =0.89, p=0.006). CONCLUSIONS: In our study, we determined pathologically that RTA treatment was not effective below 110 ° C. Therefore, we believe that RTA technique has not yet been used in clinical use according to the results of our study, and further studies are needed in order to be able to enter into clinical use.

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Radiofrequency , Thermal ablation , Cystic echinococcosis , Pulmonary cysts

Kocatepe Medical Journal

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Kocatepe Medical Journal