Author/Authors
DEMİR, Ersin Fırat Üniversitesi - Fen Fakültesi - Biyoloji Bölümü, Turkey , YILMAZ, Ökkeş Fırat Üniversitesi - Fen Fakültesi - Biyoloji Bölümü, Turkey
Title Of Article
Effect of Pine Oil on Antihyperglycemic and Some Biochemical Parameters in serum of Streptozotocin Induced Tip-2 Diabetic rats
شماره ركورد
43818
Abstract
The present study was designed to evaluate the effect of pine oil on hyperglycemia and some biochemical parameters in streptozotocin-induced type- 2 diabetic rats. Rats were divided into three groups: control (C) diabetes (STZ-DM), diabetes+pine oil (STZ-DM+PO) grups. Diabetes induced in rats by a single intraperitoneal injection of streptozotocin (45 mg/kg). 1 ml/kg the dose pine oil was intraperitoneally injected twice in a week to the diabetes+pine oil (STZ-DM+PO), plus 1 g/L dose of pure pine oil was added to drinking water of these group. According to our analysis results; fasting blood glucose levels were significantly decreased (p 0.001) in STZ-DM+PO group when compared to STZ-DM group. In addition, body weight was found to increase significantly (p 0.001) in STZ-DM+PO compared to STZ-DM group. MDA-TBA levels in serum decreased significantly (p 0.001) in STZ-DM+PO group in comparison to STZ-DM group. While compared to control group; vitamin K2, vitamin D3, α-tocopherol, retinol, cholesterol and sterols level were significantly (p 0.001) increased in STZ-DM group. Also when compared to STZ-DM group; vitamin K2, α-tocopherol and sterols levels decreased significantly (p 0.001), vitamin D3, retinol, vitamin K and cholesterol levels increased significantly (p 0.001) in the sera of STZ-DM+PO group. According to our results; stearic acid, oleic acid, linoleic acid levels were significantly (p 0.001) increased in control groups and also stearic acid, oleic acid, linoleic acid levels decreased significantly (p 0.001), palmitoleic acid level increased significantly (p 0.001) in the serum of STZ-DM+PO group when both of the groups compared to STZ-DM group. This study demonstrates that pine oil possesses hypoglycemic potentials in STZ induced diabetic rats and concluded that pine oil has positive effect on some biochemical parameters in the serum.
From Page
140
NaturalLanguageKeyword
Hyperglycemia , pine oil , lipid peroxidation , antioxidant activity , fatty acid
JournalTitle
International journal of advances in engineering and pure sciences
To Page
156
JournalTitle
International journal of advances in engineering and pure sciences
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