Effects of Pine Oil Aganist Some Biochemical Parametres Occurring Muscle Tissue of The Rats İnduced Type-1 Diabetes

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The present study was designed to evaluate the impact of pine oil on some biochemical parameters in muscle tissue of streptozotocin-induced type-1diabetic rats. The rats were divided into three groups: control (C) streptozotocin (STZ), streptozotocin+pine oil (STZ+PO) grups. Diabetes induced in rats by a single intraperitoneal injection of streptozotocin (65 mg/kg). 1 mL/kg the dose pine oil was intraperitoneally injected twice in a week to the streptozotocin+pine oil (STZ+PO), and additionally 0.5 mL /500 mL dose of pine oil was added to drinking water of these group. MDA levels of muscle tissue was increased significantly (p 0,001) in STZ group and glutathione (GSH) level muscle tissue was decreased significantly (p 0,001) when compared to control group. It was detected that MDA levels of muscle tissue significantly was decreased (p 0,001) and GSH level was significantly (p 0,001) inreased in the STZ+PO group compared to STZ group. The fatty acid composition, A, D, E and K vitamins, cholesterol and sterol levels significantly were changed in the control group compared to STZ group, in addition to, the applied pine oil can significantly inhibited these changes in muscle tissue. According to our findings, it was observed that the pine oil has beneficial effects in the decreasing of some biochemical metabolic disorders caused by experimental diabetes in the muscle tissue.

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Experimental diabetes , oxidative stress , fatty acid composition , A , D , E and K vitamins , cholesterol and sterols

International journal of advances in engineering and pure sciences

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International journal of advances in engineering and pure sciences