Author/Authors
tüzmen, şükrü eastern mediterranean university - faculty of arts and sciences - molecular biology and genetics program, department of biological sciences, Famagusta, Turkey , yalinca, zülal eastern mediterranean university - faculty of arts and sciences - department of chemistry, Famagusta, turkey
Title Of Article
ATTRACTIVE APPROACHES IN siRNA DELIVERY USING POLYMER BIO-BASED CARRIER SYSTEMS
شماره ركورد
44657
Abstract
Functional characterization of genes can be determined by disruption of gene expression. This provides powerful approach in designing novel treatment strategies. RNA interference (RNAi) is a natural phenomenon that can aid in the study of post-transcriptional regulation of genes. This mechanism can be stimulated via introduction of double stranded RNA (dsRNA) in a cell. Synthetic short/small interfering RNAs (siRNA) can be utilized to trigger down-regulation of desired genes via transfecting into mammalian cells. Recently, utilization of polymeric carriers has been an attractive approach in drug delivery for medical applications. This review article describes the advantages of exploiting polymeric carriers for siRNA delivery, as bio-therapeutics. Here, we report the current developments, safety and delivery of bio-based siRNAs via polymeric carriers. Additionally, cancer genetics and metabolic disorders including obesity and diabetes pertaining to the progress in clinical applications have been highlighted.
From Page
74
NaturalLanguageKeyword
siRNA , bio , therapeutics , Post , transcriptional regulation , Polymeric delivery systems
JournalTitle
Anadolu University Journal of Science and Technology C - Life Sciences and Biotechnology
To Page
89
JournalTitle
Anadolu University Journal of Science and Technology C - Life Sciences and Biotechnology
Link To Document