Author/Authors
ayaz, furkan mersin university - faculty of arts and science - biotechnology department, Mersin, Turkey , isse, qadar ahmed mersin university - faculty of arts and science - biotechnology department, Mersin, Turkey , kheeree, rusmeenee mersin university - faculty of arts and science - biotechnology department, Mersin, Turkey , ersan, ronak haj mersin university - faculty of pharmacy, Mersin, Turkey , algül, öztekin mersin university - faculty of pharmacy, Mersin, Turkey
Title Of Article
BISBENZOXAZOLE DERIVATIVES HAD ANTI-PROLIFERATIVE EFFECT ON HUMAN CANCER CELLS
شماره ركورد
44681
Abstract
A series of symmetric bis-benzoxazole derivatives were synthesized using one-pot cyclisation reaction between 4-fluoro substituted 2-aminophenol and suitable carboxylic acids. Synthesized compounds’ anticancer activities were tested by using MTT assay on human prostate (DU145) and breast (MCF7) cancer cells. Screening results revealed that all compounds possessed a high level anti-cancer potential by significantly decreasing the cell proliferation in prostate and breast cancer cell lines. Our compounds exerted their anti-proliferative effects in a dose and time dependent manner. Our results suggest that they can be highly potent since they were biologically active even at low concentration ranges. Our study presents a series of new bis-benzoxazole based compounds with potential therapeutic effects against tumor cells. Therefore, characterization of new generation bis-benzoxazole derivatives will have a significant contribution on the development of new era anti-cancer drug candidates.
From Page
203
NaturalLanguageKeyword
Bisbenzoxazole , Breast cancer , Prostate cancer , Anti , proliferative , Anti , cancer
JournalTitle
Anadolu University Journal of Science and Technology C - Life Sciences and Biotechnology
To Page
211
JournalTitle
Anadolu University Journal of Science and Technology C - Life Sciences and Biotechnology
Link To Document