Author/Authors
ünal, orhan akdeniz üniversitesi - fen fakültesi - biyoloji bölümü, Antalya, Turkey , ünal, aytül akdeniz üniversitesi - fen fakültesi - biyoloji bölümü, ANTALYA, turkey , çetin, seyit alper akdeniz üniversitesi - fen fakültesi - biyoloji bölümü, ANTALYA, turkey , aydemir, esra akdeniz üniversitesi - fen fakültesi - biyoloji bölümü, ANTALYA, Turkey , bayram, edip akdeniz üniversitesi - fen fakültesi - kimya bölümü, ANTALYA, Turkey , kızıl, çağdaş akdeniz üniversitesi - fen fakültesi - kimya bölümü, ANTALYA, turkey
Title Of Article
Investigation of The Anticancer Effects of Graphene Oxide (GO), Nitrogen Doped Graphene Oxide (NGN-OXIDE) and Nitrogen Doped Graphene (NGN)
شماره ركورد
44908
Abstract
Graphene oxide (GO), Nitrogen-doped graphene oxide (NGN-OXIDE), nitrogen-doped graphene (NGN) and MCF-7 (ATCC® HTB-22™, estrogen receptor positive human breast cancer), A549 (ATCC® CCL-185) human lung epithelial carcinoma), 293-T (ATTC CRL-1573, human embryonic kidney epithelium) cell lines were used in this research.A549 showed the greatest effect on viability of lung carcinoma cells. After an incubation period of 24 hours, the IC50 value for NGN was 195 μg/ml. The same cells have an IC50 value of 833 μg/ml for NGN-OXIDE. Graphene oxide caused only 17% death in A549 cells at the highest dose of 1000 μg/ml.NGN showed the greatest effect on the viability of MCF-7 breast cancer cells. At the end of the 24 hour incubation period, the IC50 value for NGN was 377 μg/ml. The same cells, NGN-OXIDE and grapheneoxide, showed the greatest effect at the lowest tested dose of 1.9 μg/ml, resulting in 18% and 11% deaths, respectively.
From Page
193
NaturalLanguageKeyword
Graphene Oxide , Nitrogen Additive Graphene Oxide , Nitrogen Doped Graphene , Anticancer
JournalTitle
Erciyes University Journal Of The Institute Of Science and Technology
To Page
203
JournalTitle
Erciyes University Journal Of The Institute Of Science and Technology
Link To Document