Author/Authors
elmeskini, ihsane université sidi mohammed ben abdellah - laboratoire de chimie organique, Fès, morocco , toupet, loic université de rennes - institut de physique, ipr, Rennes, France , daoudi, maria université sidi mohammed ben abdellah - laboratoire de chimie organique, Fès, Morocco , kerbal, abdelali université sidi mohammed ben abdellah - laboratoire de chimie organique, Fès, Morocco , moreira, diogo r. m. federal university of pernambuco - laboratory for the planning, synthesis and evaluation of pharmaceutical products, Recife, Brazil , hadda, taibi b. université medicine 1ier - laboratoire de chimie des matériaux, Oujda, Morocco
Title Of Article
IS IT POSSIBLE FOR THE 2-[(4-CHLORO-PHENYL)-(3,5-DIMETHYLPYRAZOL- 1-YL)-METHYL]-MALONIC ACID DIETHYL ESTER TO PRESENT A POTENTIAL CANDIDATE HIV-INTEGRASE INHIBITOR ON THE BASIS OF ITS O,N,O-LIGAND STRUCTURE
شماره ركورد
45167
Abstract
The titled new functionalized ligand of type 2-[(aryl)-(cycloaminilyl)-methyl]- malonic acid diethyl ester (4) is prepared in good yield through condensation of 3,5- dimethylpyrazole, with 2-arylidene-malonic acid diethyl esters 3. The structure of 4 was determined by spectral (IR, 1H NMR), elemental analyses and X-ray diffraction data. The molecular conformation shows two possible pockets ready to coordinate two metal atoms.
From Page
36
NaturalLanguageKeyword
Polydentate O , N , O , ligand , b , amino dicarbonyl compound , malonate , Michael reaction , aqueous medium
JournalTitle
Journal Marocain De Chimie Hétérocyclique
To Page
45
JournalTitle
Journal Marocain De Chimie Hétérocyclique
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