Title :
Biotelemetry of cardiovascular hemodynamic measurements in miniswine
Author :
Pitsillides, K.F. ; Symons, J.D. ; Longhurst, J.C.
Author_Institution :
Dept. of Internal Med., California Univ., Davis, CA, USA
Abstract :
A three-channel biotelemetry system has been designed and implemented for use in a chronically instrumented animal model of cardiovascular disease. A dual-channel ultrasonic transit-time micrometer allows monitoring of left-ventricular wall motion for the regions perfused by the left circumflex and left anterior descending coronary arteries. A third channel provides left ventricular blood pressure obtained from a high-fidelity blood pressure transducer implanted in the left ventricle. The biotelemetry system features a high voltage DC-DC converter for improved ultrasonic signal strength, a time-to-voltage converter that is highly immune to synchronization frequency variations, low power consumption (approx. 100 mW), small size (4*6*12 cm), and low weight (approx. 200 g). This three-channel system has been used to continuously monitor untethered animals for 24-h periods. The data can be utilized to quantify myocardial oxygen demand and regional left-ventricular wall thickening.
Keywords :
biological techniques and instruments; cardiology; haemodynamics; pressure measurement; telemetering systems; 100 mW; 12 cm; 24 hr; 3-channel biotelemetry system; 4 cm; 6 cm; cardiovascular disease; cardiovascular hemodynamic measurements; chronically instrumented animal model; dual-channel ultrasonic transit-time micrometer; high-fidelity blood pressure transducer; left anterior descending coronary artery; left circumflex artery; left-ventricular wall motion monitoring; miniswine; myocardial O/sub 2/ demand quantification; regional left-ventricular wall thickening; synchronization frequency variations; time-to-voltage converter; ultrasonic signal strength; Animals; Biomedical monitoring; Biomedical telemetry; Blood pressure; Cardiology; Cardiovascular diseases; DC-DC power converters; Hemodynamics; Instruments; Ultrasonic variables measurement; Animals; Cardiovascular Diseases; Chronic Disease; Disease Models, Animal; Echocardiography; Equipment Design; Evaluation Studies as Topic; Hemodynamics; Prostheses and Implants; Swine; Swine, Miniature; Telemetry;
Journal_Title :
Biomedical Engineering, IEEE Transactions on
