Title :
In Vivo Detection of Gold Nanoshells in Tumors Using Diffuse Optical Spectroscopy
Author :
Zaman, Raiyan T. ; Diagaradjane, Parmeswaran ; Wang, James C. ; Schwartz, Jon ; Rajaram, Narasimhan ; Gill-Sharp, Kelly L. ; Cho, Sang H. ; Rylander, Henry Grady, III ; Payne, J. Donald ; Krishnan, Sunil ; Tunnell, James W.
Author_Institution :
Univ. of Texas at Austin, Austin
Abstract :
This study demonstrates the use of diffuse optical spectroscopy (DOS) for the noninvasive measurement of gold nanoshell concentrations in tumors of live mice. We measured the diffuse optical spectra (500-800 nm) using an optical fiber probe placed in contact with the tissue surface. We performed in vitro studies on tissue phantoms illustrating an accurate measurement of gold-silica nanoshell concentration within 12.6% of the known concentration. In vivo studies were performed on a mouse xenograft tumor model. DOS spectra were measured at preinjection, immediately postinjection, 1 and 24 h postinjection times, and the nanoshell concentrations were verified using neutron activation analysis.
Keywords :
biomedical optical imaging; gold; nanostructured materials; visible spectroscopy; Au; DOS; diffuse optical spectra; diffuse optical spectroscopy; gold nanoshells; in vivo detection; live mice; mouse xenograft tumor model; neutron activation analysis; noninvasive measurement; optical fiber probe; tissue phantoms; tumors; Gold; In vitro; In vivo; Mice; Neoplasms; Noninvasive treatment; Optical fibers; Performance evaluation; Probes; Spectroscopy; Contrast agents; diffuse optical spectroscopy (DOS); diffusion theory; gold nanoparticles; optical imaging;
Journal_Title :
Selected Topics in Quantum Electronics, IEEE Journal of
DOI :
10.1109/JSTQE.2007.910804
