DocumentCode
1031457
Title
Cloning pigs as organ donors for humans
Author
Lai, Liangxue ; Prather, Randall S.
Author_Institution
Dept. of Animal Sci., Missouri Univ., Columbia, MO, USA
Volume
23
Issue
2
fYear
2004
Firstpage
37
Lastpage
42
Abstract
In order to overcome this shortage of organs, scientists have considered the possibility of using animals as a source of organs. Xenotransplantation, or xenografting, is the process of transplanting live organs between different species. ne choice of source animals will be of prime importance for xenotransplantation. Ideally, the donor animal would show immunological, anatomical, and physiological similarities to humans, possess organs of similar size to those of humans, would have a short generation interval, produce large litters, and show minimal risk of transmitting infectious agents to humans. Two groups of animals have been considered as potential donors: nonhuman primates and pigs. For several reasons, pigs, rather than nonhuman primates, are currently viewed as the most promising xenograft donors.
Keywords
genetic engineering; kidney; liver; patient treatment; skin; Xenotransplantation; anatomical; hearts; human-to-human transplantation; immunological; kidneys; live organs; livers; lungs; organ transplants; organs; pancreas; physiological similarities; pigs; xenograft donors; xenografting; Animal structures; Cells (biology); Cloning; Diseases; Human immunodeficiency virus; In vitro; Liver; Organisms; Pathogens; Viruses (medical);
fLanguage
English
Journal_Title
Engineering in Medicine and Biology Magazine, IEEE
Publisher
ieee
ISSN
0739-5175
Type
jour
DOI
10.1109/MEMB.2004.1310972
Filename
1310972
Link To Document