Transient Temperature Response of Pulsed-Laser-Induced Heating for Nanoshell-Based Hyperthermia Treatment

This paper aims to address the transient phenomenon in pulsed-laser-induced heating for nanoshell-based hyperthermia. Within the framework of dual phase lag model, the transient temperature with the relaxation behavior involved was compared with that based on Fourier´s law. The temporal variation of temperature is investigated under the irradiation of pulsed laser, as well as continuous-wave (CW) laser. A semianalytical solution of 1-D nonhomogenous dual phase lag equation in spherical coordinates is presented. The results show that the transient temperature with relaxation behavior considered is generally higher than that predicted by a classical diffusion model. The magnitude of difference depends on pulsewidth, duty cycle, and repetition rate. The maximal transient temperature is as high as 350 times the steady-state temperature in a CW case. The biological effect caused by the overheating in a short period needs to be studied further.