Title :
Scanning mass spectrometry probe for biochemical imaging
Author :
Fedorov, A.G. ; Degertekin, F.L.
Author_Institution :
George W. Woodruff Sch. of Mech. Eng., Georgia Inst. of Technol., Atlanta, GA, USA
fDate :
7/6/2006 12:00:00 AM
Abstract :
A novel ion source concept for sampling and ionising molecules for mass spectrometric analysis which is amenable for integration with an atomic force microscope is described. This combination enables simultaneous imaging of the topography of complex biological samples as well as their local biochemical make-up. The resulting scanning mass spectrometry probe has potential to become a new tool for spatially and temporally resolved, in-situ mass spectrometric analysis of biological tissues or even a single cell.
Keywords :
atomic force microscopy; biochemistry; biological techniques; biological tissues; biomedical imaging; cellular biophysics; mass spectroscopy; atomic force microscope; biochemical imaging; biochemical make-up; biological cells; biological tissues; scanning mass spectrometry probe;
Journal_Title :
Electronics Letters
DOI :
10.1049/el:20060814
