DocumentCode
1063947
Title
Biologic computational building blocks
Author
Capstick, Myles H. ; Marnane, W. P Liam ; Pethig, Ronald
Author_Institution
Inst. of Molecular & Biomolecular Electron., Wales Univ., Bangor, UK
Volume
25
Issue
11
fYear
1992
Firstpage
22
Lastpage
29
Abstract
Methods to represent the biological activity of oxidoreductase enzymes using logic state diagrams and to simulate the enzymes´ functionings using synchronous sequential digital circuits are presented. The steps of this transform from biologics to logic involve the enzymes ´electron kinetic behavior, which reveals the basic reaction pathways of the enzyme building blocks. Because these pathways are well defined, with each enzyme going through several different conformations, each conformation can be defined in terms of a logic state. The definitions can be used to describe a state machine for the enzyme building block.<>
Keywords
automata theory; biomolecular electronics; proteins; sequential circuits; biological activity; electron kinetic behavior; enzyme building block; enzymes´ functionings; logic state diagrams; oxidoreductase enzymes; state machine; synchronous sequential digital circuits; Biochemistry; Biological system modeling; Biology computing; Circuit simulation; Computational modeling; Digital circuits; Electrons; Kinetic theory; Logic; Sequential circuits;
fLanguage
English
Journal_Title
Computer
Publisher
ieee
ISSN
0018-9162
Type
jour
DOI
10.1109/2.166401
Filename
166401
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