• DocumentCode
    1063947
  • Title

    Biologic computational building blocks

  • Author

    Capstick, Myles H. ; Marnane, W. P Liam ; Pethig, Ronald

  • Author_Institution
    Inst. of Molecular & Biomolecular Electron., Wales Univ., Bangor, UK
  • Volume
    25
  • Issue
    11
  • fYear
    1992
  • Firstpage
    22
  • Lastpage
    29
  • Abstract
    Methods to represent the biological activity of oxidoreductase enzymes using logic state diagrams and to simulate the enzymes´ functionings using synchronous sequential digital circuits are presented. The steps of this transform from biologics to logic involve the enzymes ´electron kinetic behavior, which reveals the basic reaction pathways of the enzyme building blocks. Because these pathways are well defined, with each enzyme going through several different conformations, each conformation can be defined in terms of a logic state. The definitions can be used to describe a state machine for the enzyme building block.<>
  • Keywords
    automata theory; biomolecular electronics; proteins; sequential circuits; biological activity; electron kinetic behavior; enzyme building block; enzymes´ functionings; logic state diagrams; oxidoreductase enzymes; state machine; synchronous sequential digital circuits; Biochemistry; Biological system modeling; Biology computing; Circuit simulation; Computational modeling; Digital circuits; Electrons; Kinetic theory; Logic; Sequential circuits;
  • fLanguage
    English
  • Journal_Title
    Computer
  • Publisher
    ieee
  • ISSN
    0018-9162
  • Type

    jour

  • DOI
    10.1109/2.166401
  • Filename
    166401