Electrokinetic microchip-based sample loading for surface plasmon resonance detection

In this reported work, a microfluidic-based fluid electrokinetic force has been used for surface plasmon resonance or surface plasmon resonance image (SPRI) detection. In this device, a modified rectangular microarray of Au instead of previous reported square or circular gold segments was designed and microfabricated with gold segment geometries and characterised by surface morphology studies. A voltage drop of maximal 400 V/cm was applied without gold erosion to drive fluorescein isothiocyanate isomer I in a high-conductivity medium on the bare gold surface layer, enabling SPRI detection.