Title :
Dendrimers in medical nanotechnology
Author :
Barrett, Tristan ; Ravizzini, Gregory ; Choyke, Peter L. ; Kobayashi, Hisataka
Author_Institution :
Addenbrookes´´ Hosp., Cambridge
Abstract :
Dendrimers are a class of highly branched synthetic polymers that form spherical macromolecules that can be reliably synthesized to a specific physical size in a highly reproducible manner. Dendrimers of different generations are chemically related to each other, allowing the study of molecular size without the interfering variable of different chemical structures.
Keywords :
molecular biophysics; nanobiotechnology; polymers; chemical structure; dendrimers; medical nanotechnology; spherical macromolecules; synthetic polymers; Biomedical imaging; Chemicals; Computed tomography; Drugs; Magnetic resonance imaging; Nanotechnology; Neoplasms; Optical imaging; Paramagnetic resonance; Permeability; Animals; Antineoplastic Agents; Boron Neutron Capture Therapy; Contrast Media; Dendrimers; Diagnostic Imaging; Drug Delivery Systems; Humans; Image Interpretation, Computer-Assisted; Magnetic Resonance Imaging; Microscopy, Electron, Transmission; Nanotechnology; Nuclear Medicine; Polyamines; Polyethylene Glycols; Radioimmunotherapy;
Journal_Title :
Engineering in Medicine and Biology Magazine, IEEE
DOI :
10.1109/MEMB.2008.931012
