DocumentCode :
1068713
Title :
Development of Magnetic Field Control for Magnetically Targeted Drug Delivery System Using a Superconducting Magnet
Author :
Mishima, Fumihito ; Takeda, Shin-Ichi ; Izumi, Yoshinobu ; Nishijima, Shigehiro
Author_Institution :
Osaka Univ., Osaka
Volume :
17
Issue :
2
fYear :
2007
fDate :
6/1/2007 12:00:00 AM
Firstpage :
2303
Lastpage :
2306
Abstract :
We have been developing the device for magnetically targeted drug delivery system (MT-DDS), which can allow us to navigate and to accumulate the drug at the local diseased part inside the body by controlling to magnetic field strength and/or gradient generated by the superconducting magnets. In considering an application of this technique to the network of the blood vessel, a number of magnets should be placed within a small region. The magnetic field at the branching point is superimposed the fields from the magnets. The optimal arrangement of magnetic field for MT-DDS was calculated and experimental verification was made using several different sizes of Y-shaped glass tubes with multiple branching points as a model system of blood vessel. Ferromagnetic particles were injected into the Y-shape glass tube and were navigated by the magnetic field which was generated by the magnet optimally arranged based on the calculation. The ratio of the amount of the navigated ferromagnetic particle to the dosed amount was measured as magnetic navigation efficiency. It is found that experimental result of magnetic navigation efficiency agreed with the calculation results, which shows that magnetic navigation by the superconducting magnet can be a promising way for realization of MT-DDS.
Keywords :
drug delivery systems; ferromagnetic materials; magnetic particles; medical control systems; superconducting magnets; blood vessel; drug delivery system; ferromagnetic particles; magnetic field control; superconducting magnet; Blood vessels; Control systems; Glass; Magnetic devices; Magnetic field measurement; Magnetic fields; Navigation; Particle measurements; Superconducting magnets; Targeted drug delivery; Ferromagnetic particle; MT-DDS; navigation; superconducting magnets;
fLanguage :
English
Journal_Title :
Applied Superconductivity, IEEE Transactions on
Publisher :
ieee
ISSN :
1051-8223
Type :
jour
DOI :
10.1109/TASC.2007.898413
Filename :
4277603
Link To Document :
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