Title :
Nanoparticle delivery enhancement with acoustically activated microbubbles
Author :
Mullin, L.B. ; Phillips, L.C. ; Dayton, P.A.
Author_Institution :
Joint Dept. of Biomed. Eng., Univ. of North Carolina at Chapel Hill, Chapel Hill, NC, USA
Abstract :
The application of microbubbles and ultrasound to deliver nanoparticle carriers for drug and gene delivery is an area that has expanded greatly in recent years. Under ultrasound exposure, microbubbles can enhance nanoparticle delivery by increasing cellular and vascular permeability. In this review, the underlying mechanisms of enhanced nanoparticle delivery with ultrasound and microbubbles and various proposed delivery techniques are discussed. Additionally, types of nanoparticles currently being investigated in preclinical studies, as well as the general limitations and benefits of a microbubble- based approach to nanoparticle delivery, are reviewed.
Keywords :
biomedical ultrasonics; bubbles; cellular biophysics; drug delivery systems; gene therapy; nanomedicine; nanoparticles; permeability; acoustically activated microbubbles; cellular permeability; drug delivery; gene delivery; microbubble-based approach; nanoparticle carriers; nanoparticle delivery enhancement; ultrasound application; vascular permeability; Acoustics; Drugs; Nanoparticles; Permeability; Plastics; Tumors; Ultrasonic imaging; Animals; Gene Transfer Techniques; Mice; Microbubbles; Nanoparticles; Ultrasonics;
Journal_Title :
Ultrasonics, Ferroelectrics, and Frequency Control, IEEE Transactions on
DOI :
10.1109/TUFFC.2013.2538
