Title :
Real-time volume measurements in the isolated beating rat heart
Author :
Waksman, Daniel G. ; McInerney, Joseph J. ; Herr, Michael D.
Author_Institution :
Dept. of Med. & Bioengineering, Pennsylvania State Univ., Hershey, PA, USA
fDate :
4/1/1994 12:00:00 AM
Abstract :
A new technique, utilizing scattered X-rays, has been developed that is capable of measuring isolated working rat heart left ventricular (LV) volumes continuously throughout the cardiac cycle. The technique was validated by comparing cardiac outputs measured via fluid collections (r=0.959, n=10). The new methodology will permit real-time measurements of pressure-volume relationships, stroke work, and indexes of diastolic function in the isolated working rat heart.
Keywords :
X-ray applications; biological techniques and instruments; cardiology; volume measurement; biophysical technique; cardiac cycle; cardiac output; diastolic function indexes; fluid collection; isolated beating rat heart; pressure-volume relationships; real-time volume measurements; scattered X-rays technique; stroke work; Biomedical measurements; Electromagnetic measurements; Electromagnetic scattering; Heart; Pressure measurement; Time measurement; Volume measurement; X-ray detection; X-ray detectors; X-ray scattering; Animals; Cardiac Output; Diastole; Evaluation Studies as Topic; Models, Cardiovascular; Myocardial Contraction; Rats; Rats, Sprague-Dawley; Reproducibility of Results; Scattering, Radiation; Signal Processing, Computer-Assisted; Ventricular Function, Left;
Journal_Title :
Biomedical Engineering, IEEE Transactions on
