Title :
Linearized method: A new approach for kinetic analysis of central dopamine D2 receptor specific binding
Author :
Watabe, Hiroshi ; Hatazawa, Jun ; Ishiwata, Kiichi ; Ido, Tatsuo ; Itoh, Masatoshi ; Iwata, Ren ; Takahashi, Toshihiro ; Hatano, Kentaro ; Nakamura, Takashi
Author_Institution :
Nat. Cardiovascular Centre Res. Inst., Osaka, Japan
fDate :
12/1/1995 12:00:00 AM
Abstract :
We proposed a new method (`linearized method´) to analyze neuroleptic ligand-receptor specific binding in a human brain using positron emission tomography (PET). We derived the linear equation to solve four rate constants, k3, k4, k5, k6 from PET data. This method does not demand a radioactivity curve in plasma as an input function to the brain, and can perform fast calculations in order to determine rate constants. We also tested the nonlinearized method including nonlinear equations which is a conventional analysis using plasma radioactivity corrected for ligand metabolites as an input function. We applied these methods to evaluate dopamine D2 receptor specific binding of [11C] YM-09151-2. The value of Bmax/Kd=k3/k 4 obtained by the linearized method was 5.72±3.1 which was consistent with the value of 5.78±3.4 obtained by the nonlinearized method
Keywords :
blood; brain; brain models; positron emission tomography; PET; central dopamine D2 receptor specific binding; human brain; input function; kinetic analysis; ligand metabolites; linear equation; linearized method; neuroleptic ligand-receptor specific binding; nonlinear equations; nonlinearized method; plasma radioactivity; positron emission tomography; radioactivity curve; rate constants; Blood vessels; Brain modeling; Cyclotrons; Kinetic theory; Nonlinear equations; Plasmas; Positron emission tomography; Sampling methods; Testing; Visualization;
Journal_Title :
Medical Imaging, IEEE Transactions on