DocumentCode :
1086222
Title :
Diode Opening Switch Based Nanosecond High Voltage Pulse Generators for Biological and Medical Applications
Author :
Tang, Tao ; Wang, Fei ; Kuthi, Andras ; Gundersen, Martin A.
Author_Institution :
Univ. of Southern California, Los Angeles
Volume :
14
Issue :
4
fYear :
2007
Firstpage :
878
Lastpage :
883
Abstract :
Studies of short (few ns) pulse cell electroperturbation require high-voltage nanosecond pulses delivered to low-impedance (10 Omega) electroporation cuvette loads. Here we present two pulse generators for these applications. The generators comprise of three stages of pulse modulation: an LC resonant stage switched by IGBT/MOSFET; a magnetic pulse compression stage; and a diode opening switch output stage. The all-solid-state design results in reproducible pulses and reliable, long-life operation. Pulses produced by the LC resonant stage are compressed using nonlinear properties of the magnetic material. The compressed pulses are fed to the diode opening switch, which is constructed by series and parallel connecting ordinary automotive rectifying diodes. Two versions of the pulse generator are described: The first version is capable of generating 20 ns wide, 4.5 kV amplitude pulses of 20 Hz repetition rate. A second version generates 5 ns, 7.5 kV amplitude pulses into the same 10 Omega cuvette load.
Keywords :
MOSFET; biomedical electronics; insulated gate bipolar transistors; pulse compression; pulse generators; pulse modulation; pulsed power switches; rectifying circuits; semiconductor diodes; IGBT; LC resonant stage; MOSFET; automotive rectifying diodes; biological cells; diode opening switch; electroperturbation; electroporation cuvette loads; magnetic pulse compression; nanosecond high voltage pulse generators; pulse modulation; Biomedical equipment; Diodes; Magnetic resonance; Magnetic switching; Medical services; Nanobioscience; Pulse compression methods; Pulse generation; Switches; Voltage;
fLanguage :
English
Journal_Title :
Dielectrics and Electrical Insulation, IEEE Transactions on
Publisher :
ieee
ISSN :
1070-9878
Type :
jour
DOI :
10.1109/TDEI.2007.4286519
Filename :
4286519
Link To Document :
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