Quantitative SPECT imaging with indium-111

Author

Gilland, D.R. ; Jaszczak, R.J. ; Turkington, T.G. ; Greer, K.L. ; Coleman, R.E.

Author_Institution

Dept. of Radiol., Duke Univ. Med. Center, Durham, NC, USA

Volume

38

Issue

2

fYear

1991

fDate

4/1/1991 12:00:00 AM

Firstpage

761

Lastpage

766

Abstract

The potential of SPECT (single photon emission computed tomography) to quantify the distribution of indium-111 was investigated in an experimental phantom study. Nonuniform attenuation compensation using acquired transmission data was compared to uniform compensation based on reconstructed quantitative accuracy and noise. The reconstructed transmission data provided the attenuation map for the nonuniform compensation. Results showed that nonuniform attenuation compensation improved image quality, quantitative accuracy, and noise compared to uniform compensation. Noise increased with a decrease in counts in the nonuniform attenuation map but remained substantially below the uniform compensation level. The noise effect was observed with both Chang and ML-EM (maximum-likelihood expectation-maximization) reconstruction methods. Independent reconstruction of the 172- and 247-keV emission data was compared to the reconstruction of the combined 172- and 247-keV projection data. Improved quantitative accuracy and image noise resulted when both In-111 emission energies were used. However, independent reconstruction of the two energies did not substantially improve accuracy or noise compared with the reconstruction of the combined data

Keywords

computerised tomography; radioisotope scanning and imaging; 172 keV; 247 keV; ¹¹¹In; image noise; image quality; maximum-likelihood expectation-maximization; medical diagnostic imaging; nonuniform attenuation compensation; nuclear medicine; quantitative SPECT imaging; quantitative accuracy; single photon emission computed tomography; uniform compensation; Attenuation; Biomedical imaging; Image quality; Image reconstruction; Imaging phantoms; In vivo; Noise level; Radiology; Reconstruction algorithms; Scattering;

fLanguage

English

Journal_Title

Nuclear Science, IEEE Transactions on

Publisher

ieee

ISSN

0018-9499

Type

jour

DOI

10.1109/23.289386

Filename

289386