Research and Development of Magnetic Drug Delivery System Using Bulk High Temperature Superconducting Magnet

Author

Nishijima, Shigehiro ; Mishima, Fumihito ; Tabata, Yasuhiko ; Iseki, Hiroshi ; Muragaki, Yoshihiro ; Sasaki, Akira ; Saho, Norihide

Author_Institution

Div. of Sustainable Energy & Environ. Eng., Osaka Univ., Suita, Japan

Volume

19

Issue

3

fYear

2009

fDate

6/1/2009 12:00:00 AM

Firstpage

2257

Lastpage

2260

Abstract

The magnetic force control of the drug motion in the body has been studied in the current work. The calculation was made to study the possibility of the magnetic force control of the drag motion from outside of the body. The condition which enables the magnetic force control was clarified. The magnetic drug delivery system (MDDS) was demonstrated to be possible using the rat and permanent magnet and the validity of the calculation was confirmed by experiment. The magnetite suspension was introduced into a liver through portal vein in the rat experiment. A permanent magnet was used to navigate the magnetite. The navigation and accumulation of the magnetite was successfully performed. Based on the results, the MDDS experiment was made with an HTS magnet for a large-sized animal, pig. The HTS magnet of which size was 45 mm in diameter and 90 mm in length produced 5 T at 38 K. The suspension of the magnetite was injected into the blood vessel of the pig. It was confirmed that the magnetite was successfully navigated and/or accumulated by the HTS magnet.

Keywords

biomedical materials; blood vessels; drug delivery systems; high-temperature superconductors; liver; magnetic forces; motion control; superconducting magnets; suspensions; HTS magnet; blood vessel; high temperature superconducting magnet; liver; magnetic drug delivery system; magnetic flux density 5 T; magnetic force control; magnetite suspension; portal vein; size 45 mm; size 90 mm; temperature 38 K; Accumulation of magnetic seeded drug; animal experiment; bulk HTS magnet; magnetic drug delivery system;

fLanguage

English

Journal_Title

Applied Superconductivity, IEEE Transactions on

Publisher

ieee

ISSN

1051-8223

Type

jour

DOI

10.1109/TASC.2009.2019288

Filename

5109597